Genome Institute of Singapore
National University of Singapore
Cardiovascular Research Institute
The mission in the Foo-lab, which moved from Cambridge UK and started in Singapore in 2013, is to understand “genome organisation” in heart cells. We are interested in how heart cells undergo “epigenomic remodelling” during the transition to heart disease: how this might lead to altered stress-gene responses, and how it contributes to heart failure disease progression. By exploring this area of research, we are particularly looking to discover novel mechanisms of disease that may offer new therapeutic options or new heart disease biomarkers.
Our projects involve making use of the latest genomic technologies, human explanted tissue and animal disease models. We are always on a look-out to work with people who have the same interest in this area of research.
Our lab has also been instrumental in putting together a clinical genomics programme starting with high-throughput genetic tests for patients with Inherited Cardiac Conditions (ICC). This has led to an ICC clinic which is run at the National University Heart Centre. We are also working to apply Clinical Genomics as diagnostics in the Clinical Genetics Departments at NUHkids (with A/Prof Denise Goh) and KK Women's and Children's Hospital (with Drs Angeline Lai and Saumya Jamuar).
Animal models and tissue processing, epigenetic processing, tissue ChIP, HiC, Capture-HiC, circulating cell-free DNA, genomic sequencing (clinical and research), computation, bioinformatics.
Interested in collaborating on
Strong scientists or clinician-scientists who might be interested to work in Asia in an active CV research group.
Selected publications on ncRNA and cardiovascular disease
A landscape of circular RNA expression in the human heart
Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017, 113(3):298-309.
The landscape of DNA repeat elements in human heart failure
Haider S, Cordeddu L, Robinson E, Movassagh M, Siggens L, Vujic A, Choy MK, Goddard M, Lio P, Foo R. Genome Biol. 2012, 13(10):R90.
Distinct epigenomic features in end-stage failing human hearts
Movassagh M, Choy MK, Knowles DA, Cordeddu L, Haider S, Down T, Siggens L, Vujic A, Simeoni I, Penkett C, Goddard M, Lio P, Bennett MR, Foo RS. Circulation. 2011; 124(22):2411-22.