Hannover Medical School

Department of Cardioloy and Angiology


Denise Hilfiker-Kleiner

Analysis of signal transduction pathways for physiological and pathophysiological processes in the myocardium, focusing on receptor systems that activate the JAK / STAT signal pathway and modulatory factors such as microRNAs, oxidative stress, metabolites, etc.

A particular focus is on the regulation of endogenous regeneration mechanisms with respect to cell-cell interactions, the role of paracrine factors and the nature of the cardiac niche.

Experiments in transgenic mice and cell culture are compared with observations on patients, with particular attention to gender-specific differences and the influence of hormones.

With this concept, pathomechanisms and new therapeutic approaches for peripartal cardiomyopathy, dilated cardiomyopathy, myocardial infarction, and tumor-induced cardiac cachexia are developed.

A further focus is the analysis of diagnostic markers also under the gender aspect, with the aim of developing new diagnostic tests. The focus is currently on cardiomyopathy associated with pregnancy, e.g. caused by preeclampsia and peripartal cardiomyopathy.


Carl-Neuberg-Str. 1
30625 Hannover