Hannover Medical School

Institute of Molecular and Translational Therapeutic Strategies (IMTTS)


Thomas Thum

The Institute "Molecular and Translational Therapeutic Strategies" (IMTTS) was founded in 2009 at the Hannover Medical School. A main group’s focus is the development of non-coding RNA-based therapeutic strategies in cardiovascular medicine.


Our group´s expertise resembles in vitro assays (cardiac cell culture, isolation of primary cardiac cells, isolation of adult cardiac cells, molecular biology, qPCR miRNA screening, CRISPR/Cas9 genome editing, telomer biology) and in vivo techniques (mouse myocardial infarction, hypertrophy, evaluation via echocardiography, Millar catheter). Our main focus is on the identification of novel non-coding RNAs contributing to pathological cardiac remodeling thereby serving as attractive therapeutic targets as well as biomarkers.

Interested in collaborating on

We aim to strengthen networking in the field of  non-coding RNAs.

Selected publications on lncRNA

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches
Beermann J, Piccoli MT, Viereck J, Thum TPhysiol Rev. 2016, 96(4):1297-325.

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes
de Gonzalo-Calvo D, Kenneweg F, Bang C, Toro R, van der Meer RW, Rijzewijk LJ, Smit JW, Lamb HJ, Llorente-Cortes VThum TSci Rep. 2016, 6:37354.

Long noncoding RNA Chast promotes cardiac remodeling
Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJEngelhardt S, Dandekar T, Batkai S, Thum TSci. Transl. Med. 2016, 8(326):326ra22.

Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization
Fiedler J, Breckwoldt K, Remmele CW, Hartmann D, Dittrich M, Pfanne A, Just A, Xiao K, Kunz M, Müller T, Hansen A, Geffers R, Dandekar T, Eschenhagen T, Thum T J Am Coll Cardiol. 2015, 66(18):2005-15.

Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure
Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, Lemesle G, de Groote P, Pinet FThum TCirc Res. 2014, 114(10):1569-75.



Carl-Neuberg-Str. 1
30625 Hannover