Department of Internal Medicine III - Cardiology
The research group of Benjamin Meder is investigating genome-wide mechanisms of genetic regulation in heart muscle disorders. By using advanced technologies, carefully phenotyped patient cohorts and bioinformatics, the group were first to introduce next-generation sequencing for cardiomyopathies, established novel disease genes for DCM and deciphered pathways that translate gene variation into the resulting phenotype.
- Next-Generation Sequencing
- DNA Methylation analysis
- lncRNA and miRNA biomarker research, including assay development
Interested in collaborating on
- Verfication datasets and patient cohorts
- Functional impact of novel lncRNA, circRNAs
Selected publications on lncRNA
Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity
Gast M, Schroen B, Voigt A, Haas J, Kuehl U, Lassner D, Skurk C, Escher F, Wang X, Kratzer A, Michalik K, Papageorgiou A, Peters T, Loebel M, Wilk S, Althof N, Prasanth KV, Katus H, Meder B, Nakagawa S, Scheibenbogen C, Schultheiss HP, Landmesser U, Dimmeler S, Heymans S, Poller W. J Mol Cell Biol. 2016, 8(2):178-81.