Hospices Civils de Lyon
To allow a multifaceted and optimized approach of patients with channelopathies, Pr Philippe Chevalier coordinates in Lyon expertises from 3 different structures:
The Institut Neuro-MyoGène (INMG) is a novel institute dedicated to the study of the nervous and muscular systems. It was created in 2016 in Lyon at the heart of a dense hospital network and of one of the biggest medical universities in France. The goal of the INMG is to unravel fundamental aspects of the cell biology of the muscle and nervous system from development to aging under normal and pathological conditions. Using a variety of model systems, the INMG is conducting an integrated multidisciplinary research from gene to physiological functions. One of its priorities is to develop relevant strategies to decipher multiple forms of cardiac muscular diseases, identify new therapeutic targets and foster novel strategies for innovative treatments.
We develop several such studies from iPS cells. The INMG benefits from the integration of cutting-edge fundamental research teams and renowned clinicians. The INMG is a consortium of three research organizations: the CNRS, the INSERM and the University Claude Bernard in Lyon.
The National Reference Center for Inherited Cardiac Diseases (University Hospital of Lyon) (Project coordinator) in Hospices Civils de Lyon (HCL). HCL is the second largest academic hospital in France. Pr Philippe Chevalier coordinates the National Reference Center for Inherited Cardiac Diseases since 2007 and joined the INMG in 2016. The pathology concerned are long QT syndrome, Brugada Syndrome, short QT syndrome, catecholaminergic polymorphic ventricular tachycardia, Hypertrophic cardiomyopathy, dilated cardiomyopathy, laminopathy, arrhythmogenic right ventricular cardiomyopathy, early repolarization syndrome, congenital atrioventricular block and familial atrial fibrillation. More than 1 000 patients/year are hospitalized in this department. The unit in Lyon is specialized in cardiac disorders and their genetic aspects. We are implied on diagnosis, improved care for patients, family screening and understanding of the pathophysiology. Numerous clinical and experimental studies were developed, especially oriented in the study of sudden death and AF pathophysiology. We especially set up a collection of human biological samples linked to rare diseases of the heart rhythm disorder.
The 3 French National Reference and the 22 French competence centers for rare arrhythmias are now joined in one network, CARDIOGEN, (www.filiere-cardiogen.fr) with strong links and common actions. A national database for each pathology is setting up.
The Cardiogenetic Laboratory (Dr Gilles Millat). Since 1999, the Cardiogenetic Laboratory performs the molecular diagnosis by NGS sequencing of pathologies involved in sudden cardiac deaths (more particularly cardiomyopathies and arrhythmias syndromes). Moreover, this laboratory also develops and optimizes methodological tools (in vivo and in vitro) that allow a better evaluation of the putative pathological impact of some genomic variations.
Cardiomyopathie, channelopathies, clinical research, NGS sequencing, family genetic screening.
Cardiac tissue collection, transcriptome, iPSc.
Interested in collaborating on
Animal models to characterize new mutations and new genes.