IRCCS-Policlinico San Donato

Molecular Cardiology Laboratory


Fabio Martelli

The Molecular Cardiology Laboratory at Policlinico San Donato, Italy, has worked for several years on the microRNA involvement in cardiovascular diseases, with a particular attention to microRNAs modulated by hypoxia. In the last few years, we have extended our interests to long non-coding RNAs. Both RNA sequencing and qPCR platforms were used to assess long non-coding RNA levels in hypoxic cells and, in vivo, in acute ischemia response as well as in heart failure.


  • Transcriptomics (RNA sequencing, arrays, bioinformatic analysis)

  • Cell and tissue response to hypoxia

  • Cell and tissue response to oxidative stress

  • Mouse models of ischemic diseases

  • Translational medicine

  • Biomarkers

Interested in collaborating on

Partners for large international projects that would be difficult or impossible to carry out at a single center.

Selected publications on ncRNA and cardiovascular disease

Central role of the p53 pathway in the noncoding-RNA response to oxidative stress
Fuschi P, Carrara M, Voellenkle C, Garcia-Manteiga JM, Righini P, Maimone B, Sangalli E, Villa F, Specchia C, Picozza M, Nano G, Gaetano C, Spinetti G, Puca AA, Magenta A, Martelli FAging (Albany NY). 2017, 9(12):2559-2586.

Increased BACE1-AS long noncoding RNA and β-amyloid levels in heart failure
Greco S, Zaccagnini G, Fuschi P, Voellenkle C, Carrara M, Sadeghi I, Bearzi C, Maimone B, Castelvecchio S, Stellos K, Gaetano C, Menicanti L, Martelli FCardiovasc Res. 2017, 113(5):453-463.

Long noncoding RNA dysregulation in ischemic heart failure
Greco S, Zaccagnini G, Perfetti A, Fuschi P, Valaperta R, Voellenkle C, Castelvecchio S, Gaetano C, Finato N, Beltrami AP, Menicanti L, Martelli FJ Transl Med. 2016, 14(1):183.

Implication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing
Voellenkle C, Garcia-Manteiga JM, Pedrotti S, Perfetti A, De Toma I, Da Silva D, Maimone B, Greco S, Fasanaro P, Creo P, Zaccagnini G, Gaetano CMartelli FSci Rep. 2016, 6:24141.

Noncoding RNA in age-related cardiovascular diseases
Greco S, Gorospe M, Martelli FJ Mol Cell Cardiol. 2015, 83:142-55.


via Morandi 30
San Donato Milanese 20097