IRCCS-Policlinico San Donato
Molecular Cardiology Laboratory
The Molecular Cardiology Laboratory at Policlinico San Donato, Italy, has worked for several years on the microRNA involvement in cardiovascular diseases, with a particular attention to microRNAs modulated by hypoxia. In the last few years, we have extended our interests to long non-coding RNAs. Both RNA sequencing and qPCR platforms were used to assess long non-coding RNA levels in hypoxic cells and, in vivo, in acute ischemia response as well as in heart failure.
Transcriptomics (RNA sequencing, arrays, bioinformatic analysis)
Cell and tissue response to hypoxia
Cell and tissue response to oxidative stress
Mouse models of ischemic diseases
Interested in collaborating on
Partners for large international projects that would be difficult or impossible to carry out at a single center.
Selected publications on ncRNA and cardiovascular disease
Central role of the p53 pathway in the noncoding-RNA response to oxidative stress
Fuschi P, Carrara M, Voellenkle C, Garcia-Manteiga JM, Righini P, Maimone B, Sangalli E, Villa F, Specchia C, Picozza M, Nano G, Gaetano C, Spinetti G, Puca AA, Magenta A, Martelli F. Aging (Albany NY). 2017, 9(12):2559-2586.
Increased BACE1-AS long noncoding RNA and β-amyloid levels in heart failure
Greco S, Zaccagnini G, Fuschi P, Voellenkle C, Carrara M, Sadeghi I, Bearzi C, Maimone B, Castelvecchio S, Stellos K, Gaetano C, Menicanti L, Martelli F. Cardiovasc Res. 2017, 113(5):453-463.
Long noncoding RNA dysregulation in ischemic heart failure
Greco S, Zaccagnini G, Perfetti A, Fuschi P, Valaperta R, Voellenkle C, Castelvecchio S, Gaetano C, Finato N, Beltrami AP, Menicanti L, Martelli F. J Transl Med. 2016, 14(1):183.
Implication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing
Voellenkle C, Garcia-Manteiga JM, Pedrotti S, Perfetti A, De Toma I, Da Silva D, Maimone B, Greco S, Fasanaro P, Creo P, Zaccagnini G, Gaetano C, Martelli F. Sci Rep. 2016, 6:24141.
Noncoding RNA in age-related cardiovascular diseases
Greco S, Gorospe M, Martelli F. J Mol Cell Cardiol. 2015, 83:142-55.