Luxembourg Institute of Health

Cardiovascular Research Unit

 

Yvan Devaux
Clarissa Pedrosa da C. Gomes
Lu Zhang

The Laboratory of Cardiovascular Research aims to decipher the mechanisms responsible for the development of heart failure and to identify novel cardiac biomarkers with focus on non-coding RNAs. The main goals are to enhance collaborations with public and private partners to bring research products to clinical application, pushing personalized medicine forward.

Dr Yvan Devaux is Head of the Cardiovascular Research Unit at LIH. He is founder and, together with Post-doctoral fellow Dr Clarissa P. da C. Gomes, coordinator of the Cardiolinc network.

Expertise

Using a thoroughly validated experimental pipeline including both discovery and validation phases, Yvan and his group aim to identify novel biomarkers of acute cardiac conditions such as acute myocardial infarction, cardiac arrest, heart failure, aortic stenosis and stroke. His research group focuses on RNAs and particularly non-coding RNAs (micro, long and circular).

Interested in collaborating on

We are open to collaboration in any activity related to our research goals. Particularly, translational research projects to advance personalized medicine based on non-coding RNA, and access to cohorts of patients with cardiac arrest, acute myocardial infarction, aortic dissection and stroke.

Selected publications on lncRNA

Myocardial Infarction-Associated Circular RNA Predicting Left Ventricular Dysfunction
Vausort M, Salgado-Somoza A, Zhang L, Leszek P, Scholz M, Teren A, Burkhardt R, Thiery J, Wagner DR, Devaux YJ Am Coll Cardiol. 2016, 68(11):1247-8.

Whole transcriptome microarrays identify long non-coding RNAs associated with cardiac hypertrophy
Zhang L, Hamad EA, Vausort M, Funakoshi H, Nicot N, Nazarov PV, Vallar L, Feldman AM, Wagner DR, Devaux Y; Cardiolinc network (www.cardiolinc.org). Genomics Data. 2015, 5:68-71.

Long noncoding RNAs in cardiac development and ageing
Devaux Y, Zangrando J, Schroen BCreemers EEPedrazzini TChang CPDorn II GWThum THeymans SNat Rev Cardiol. 2015, 12(7):415-25.

Identification of Candidate Long Noncoding RNAs Associated with Left Ventricular Hypertrophy
Zhang L, Hamad EA, Vausort M, Funakoshi H, Feldman AM, Wagner DR, Devaux YClin Transl Sci. 2014, 8(2):100-6.

Long noncoding RNAs in patients with acute myocardial infarction
Vausort M, Wagner DR, Devaux YCirc Res. 2014, 115(7):668-77.