Technical University of Munich
Institute of Pharmacology and Toxicology
Professor Engelhardt’s research topics are located in the field of Signal Transduction in the Cardiovascular System.
The group investigates cellular signaling mechanisms in the cardiovascular system and aims to proof their relevance in vivo. Our current efforts focus on transcriptional control of cardiac myocyte cell growth, including microRNAs as important regulators. A second focus is the analysis of ß-adrenergic receptor signaling within the myocardium. The understanding of basic, disease-related signaling mechanisms allows us to develop and test novel therapeutic strategies against cardiac disease, namely heart failure. This approach necessitates a broad methodological spectrum ranging from optical studies of receptor conformational changes to analysis of cardiac function in living mice in vivo.
Selected publications on lncRNA
Characterization of circular RNAs in human, mouse and rat hearts
Werfel S, Nothjunge S, Schwarzmayr T, Strom TM, Meitinger T, Engelhardt S. J Mol Cell Cardiol. 2016, 98:103-7.
Professor Engelhardt (born 1969) studied Medicine at the Universities of Regensburg, Munich and Harvard. After completing his MD at the MPI of Biochemistry and his PhD and a postdoctorate at the University of Würzburg, Professor Engelhardt led an independent junior research group at the Rudolf-Virchow-Center/DFG-Research Center for Experimental Biomedicine. Before joining TUM in 2008 he held a professorship of Pharmacology at Würzburg University.