University Medical Center Göttingen

Heart Research Center Göttingen


Gerd Hasenfuß
Sara Khadjeh

We are interested to understand the mechanisms underlying the transition of cardiac remodeling from compensated hypertrophy with preserved heart function to heart failure. In order to develop new therapeutic strategies, we are particularly focusing on load-depended remodeling and the analysis of epigenetics and  linc regulation of these processes.


Subject areas

Cardiology, Heart failure, Transition to failure, Gene Expression, Epigenetics

Model systems

Human myocardium biopsies, hiPSC derived cardiomyocytes, TAC mouse model

Molecular biology techniques

DNA and RNA Ilumina sequencing (MiSeq and HiSeq) including library preparation and downstream data analysis such as Pathway and Cluster analyses, DNA extraction, total RNA extraction, mRNA extraction, PCR, quantitative PCR, Rapid Amplification of cDNA ends (RACE), Molecular cloning and in vitro site-directed mutagenesis, Whole mount in situ hybridization, Immunohistochemistry, RNA interference (RNAi), LNA GapmeR mediated inhibition of lncRNAs

Interested in collaborating on

Analysis of lncRNA function


Robert-Koch-Str. 40
37075 Göttingen