University of Dundee
School of Medicine, Division of Molecular & Clinical Medicine
METFORMIN: USEFUL IN NON-DIABETIC CARDIOVASCULAR DISEASE?
A major recent focus has been metformin, which is the gold-standard treatment of insulin resistance in type 2 diabetes. The target of this drug has been unknown since the drug’s antihyperglycaemic properties were identified almost a century ago. Our work has included high-profile investigation of anti-inflammatory effects of the drug, which may contribute towards cardioprotective effects in patients and which we have found occurring irrespective of diabetes status (Cameron and co-workers (Circ. Res. 2016).
- Cell signalling
- Metabolic studies
- Gene expression
- Validation in clinical samples
Interested in collaborating on
- Inflammation in CVD