University of Eastern Finland

A.I. Virtanen Institute of Molecular Sciences

 

Seppo Ylä-Herttuala

Our research topics are the following: mechanisms of angiogenesis, VEGF biology, genetic control and regulation of growth factors involved in angiogenesis and lymphangiogenesis, gene transfer techniques, non-coding RNA biology and translational studies especially in large animal models of myocardial and peripheral ischemia.

Expertise

Major techniques: Basic and translational studies of therapeutic angiogenesis and lymphangiogenesis, gene transfer, vector biology, siRNA, miRNA and non-coding RNA analysis methods, GRO-sequencing, translational large animal models, GMP manufacturing of gene transfer vectors.

Interested in collaborating on

Biological role, regulation and applications of non-coding RNAs. Translational large animal studies in the area of therapeutic angiogenesis, lymphangiogenesis, cardiac ischemia and regeneration and peripheral vascular disease.

Selected publications on ncRNA and cardiovascular disease

Activating the chromatin by non-coding RNAs
Laham-Karam N, Laitinen P, Turunen TA, Ylä-Herttuala SAntioxid Redox Signal. 2017.

Genome-wide dynamics of nascent non-coding RNA transcription in porcine heart after myocardial infarction
Kaikkonen MU, Halonen P, Liu O, Turunen T, Pajula J, Moreau P, Selvarajan I, Tuomainen T, Aavik E, Tavi P, Ylä-Herttuala SCirculation: Cardiovascular Genetics. 10(3), 2017.

Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism
Turunen MP, Lehtola T, Heinonen SE, Assefa GS, Korpisalo P, Girnary R, Glass CK, Väisänen S, Ylä-Herttuala S. Circ. Res. 105; 604-609, 2009.

CV

Website
seppo.ylaherttuala@uef.fi

P.O. Box 1627
FI-70211 Kuopio
Finland