University of Eastern Finland

A.I. Virtanen Institute of Molecular Sciences


Seppo Ylä-Herttuala

Our research topics are the following: mechanisms of angiogenesis, VEGF biology, genetic control and regulation of growth factors involved in angiogenesis and lymphangiogenesis, gene transfer techniques, non-coding RNA biology and translational studies especially in large animal models of myocardial and peripheral ischemia.


Major techniques: Basic and translational studies of therapeutic angiogenesis and lymphangiogenesis, gene transfer, vector biology, siRNA, miRNA and non-coding RNA analysis methods, GRO-sequencing, translational large animal models, GMP manufacturing of gene transfer vectors.

Interested in collaborating on

Biological role, regulation and applications of non-coding RNAs. Translational large animal studies in the area of therapeutic angiogenesis, lymphangiogenesis, cardiac ischemia and regeneration and peripheral vascular disease.

Selected publications on lncRNA

Activating the chromatin by non-coding RNAs
Laham-Karam N, Laitinen P, Turunen TA, Ylä-Herttuala SAntioxid Redox Signal. 2017.

Genome-wide dynamics of nascent non-coding RNA transcription in porcine heart after myocardial infarction
Kaikkonen MU, Halonen P, Liu O, Turunen T, Pajula J, Moreau P, Selvarajan I, Tuomainen T, Aavik E, Tavi P, Ylä-Herttuala SCirculation: Cardiovascular Genetics. 10(3), 2017.

Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism
Turunen MP, Lehtola T, Heinonen SE, Assefa GS, Korpisalo P, Girnary R, Glass CK, Väisänen S, Ylä-Herttuala S. Circ. Res. 105; 604-609, 2009.



P.O. Box 1627
FI-70211 Kuopio