University of Frankfurt
Institute of Cardiovascular Regeneration
The Institute of Cardiovascular Regeneration is supported by the Excellence Cluster "Cardiopulmonary Systems". The Institute is dedicated to elucidate the basic mechanisms underlying cardiovascular disease and vessel growth with the aim to develop new therapies for improving the treatment of cardiovascular disease.
- Vascular biology
- RNA-protein interactions
- Therapeutic regulation of lncRNAs
- Circular RNAs
Selected publications on lncRNA
Long Noncoding RNA Meg3 Controls Endothelial Cell Aging and Function: Implications for Regenerative Angiogenesis
Boon RA, Hofmann P, Michalik KM, Lozano-Vidal N, Berghäuser D, Fischer A, Knau A, Jaé N, Schürmann C, Dimmeler S. J Am Coll Cardiol. 68(23):2589-2591.
Long Noncoding RNAs: From Clinical Genetics to Therapeutic Targets?
Boon RA, Jaé N, Holdt L, Dimmeler S. J. Am. Coll. Cardiol. 2016, 67(10):1214-26.
Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA
Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S. Circ Res. 2015, 117(10):884-90.
Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth
Michalik KM, You X, Manavski Y, Doddaballapur A, Zörnig M, Braun T, John D, Ponomareva Y, Chen W, Uchida S, Boon RA, Dimmeler S. Circ Res. 2014, 114(9):1389-97.