University of Frankfurt

Institute of Cardiovascular Regeneration


Stefanie Dimmeler
Reinier Boon

The Institute of Cardiovascular Regeneration is supported by the Excellence Cluster "Cardiopulmonary Systems". The Institute is dedicated to elucidate the basic mechanisms underlying cardiovascular disease and vessel growth with the aim to develop new therapies for improving the treatment of cardiovascular disease.


  • Vascular biology

  • RNA-protein interactions

  • Therapeutic regulation of lncRNAs

  • Circular RNAs

Selected publications on lncRNA

Long Noncoding RNA Meg3 Controls Endothelial Cell Aging and Function: Implications for Regenerative Angiogenesis
Boon RA, Hofmann P, Michalik KM, Lozano-Vidal N, Berghäuser D, Fischer A, Knau A, Jaé N, Schürmann C, Dimmeler SJ Am Coll Cardiol. 68(23):2589-2591.

Long Noncoding RNAs: From Clinical Genetics to Therapeutic Targets? 
Boon RA, Jaé N, Holdt L, Dimmeler SJ. Am. Coll. Cardiol. 2016, 67(10):1214-26.

Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA
Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S. Circ Res. 2015, 117(10):884-90.

Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth
Michalik KM, You X, Manavski Y, Doddaballapur A, Zörnig M, Braun T, John D, Ponomareva Y, Chen W, Uchida S, Boon RADimmeler SCirc Res. 2014, 114(9):1389-97.


Theodor-Stern-Kai 7
D-60590 Frankfurt