University of Leipzig
Leipzig Research Center for Civilization Diseases
Despite remarkable progress in prevention and prevention of coronary artery disease (CAD), its major clinical presentations, in particular myocardial infarction and heart insufficiency are one of the most frequent causes of mortality in Europe. The aim of LIFE Heart study is to identify the biomarkers and genetic factors predicting the initiation, art of clinical manifestation, and clinical outcome of coronary atherosclerosis.
The LIFE Heart study was initiated 2006 within the cooperation between the Institute of Laboratory Medicine and Depratment of Cardiology at Heart Center of the University of Leipzig. Since 2010, LIFE Heart is a part of LIFE Cluster of disease Cohorts investigating diverse aspects, pathophysiology and risk for major civilisation disease.
Since the recruitment of LIFE Heart was finalised, detailed data on phenotypes including coronary angiogram, echocardiography and basis laboratory analysis are available from ca 3500 patients admitted for suspected stable coronary artery disease and 3500 patients after acute coronary syndrome. Moreover, high-throughput analysis using microarrays were applied in large subpopulations of the cohort.
Currently, LIFE Heart is one of the biggest cardiovascular cohorts considering its size and the detail of phenotype characterisation. Besides the validation of established markers, novel genetic, and epigenetic RNA markers as well as mechanistic insights into related cardiovascular risk has been reported in several publications.
In further steps, LIFE aims to evaluate the identified novel risk factors in long-term follow up.
- Identification of novel clinical, genetic, and epigenetic factors that predict the course of obstructive and non-obstructive coronary atherosclerosis including high-throughput techniques and system biology
- Mechanistic insights into role of peripheral blood markers in the pathophysiology of acute coronary syndrome, obstructive, and non-obstructive stable CAD.
Interested in collaborating on
- Increasing the power to detect novel lncRNA marker in merged cohorts
- Replication of discovered lncRNA biomarkers
- Contribution on translational research including the development of diagnostic tests for clinical practice
Selected publications on lncRNA
Myocardial Infarction-Associated Circular RNA Predicting Left Ventricular Dysfunction
Vausort M, Salgado-Somoza A, Zhang L, Leszek P, Scholz M, Teren A, Burkhardt R, Thiery J, Wagner DR, Devaux Y. J Am Coll Cardiol. 2016, 68(11):1247-8.